KNOW Bio delivers the first definitive demonstration of Nitric Oxide efficacy against the SARS-CoV-2 virus.

COVID-man-cannon.png

KNOW Bio, LLC has generated the first definitive evidence that Nitric Oxide can inhibit viral reproduction of SARS-CoV-2, the human coronavirus that causes COVID-19. Nitric Oxide is a molecule produced naturally by the body to regulate blood flow, control inflammation, and defend against invading microorganisms.

“As a leader in the development of Nitric Oxide-based therapies, we felt we were best positioned to establish that Nitric Oxide is effective against this virus.”
— Neal Hunter, Chief Executive Officer, KNOW Bio, LLC
99.9-effective.png


These milestone in-vitro experiments were conducted by testing multiple Nitric Oxide-releasing compounds against wild type SARS-CoV-2 virus at an independent third-party laboratory with a deep history of antiviral research. Therapeutic doses were applied to infected cells and resulted in a greater than 99.9% reduction in the virus after 24 hours versus virus observed on untreated cells. There was no cell damage or cell death on uninfected cells.

Nitric Oxide has been reported to:

Access Rep Release Images
Inhibit infection
Inhibit infection

by altering spike protein binding and disrupting the ability of the virus to attach to the receptor and infect human cells.

Inhibit replication
Inhibit replication

inside an infected cell by slowing viral RNA production - resulting in fewer RNA strands and viral copies.

Inhibit release
Inhibit release

of reproduced virus by inhibiting host cell death via interfering with caspase activity - virus remains within the infected cell.

The medical and scientific community has long recognized the healing and protective properties of Nitric Oxide. The research at KNOW Bio has provided new understandings into the effective concentrations, rates of release and mechanism of action of Nitric Oxide against human coronavirus - providing valuable insights into safety and efficacy.

Millions of lives are being disrupted and hundreds of thousands lost to this frightening virus, our findings clearly show that Nitric Oxide-based therapeutics, need to be a part of any well-thought response to the COVID-19 pandemic.

Submission for publication and peer review is expected before year end.